Phenotypes Associated with This Genotype

Genotype
MGI:5295053

• Allelic Composition: S1pr1^tm1.1Cys/S1pr1^tm1.1Cys
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:176118 )

N • T and B cell lymph node entry is normal

N • mice exhibit normal numbers of follicular and marginal zone B cells

decreased B cell number ( J:176118 )

• in the blood

abnormal B cell physiology ( J:176118 )

• marginal zone B cells are resistant to S1P-mediated S1PR1 internalization

• marginal zone B cells exhibit increased chemotaxis response to S1P compared with control cells

• splenic follicular dendritic cells exhibit reduced deposition of phycoerythrin-induced immune complexes compared with control cells

• however, chemotaxis response to CXCL12 and CXCL13 is normal

hematopoietic system

decreased B cell number ( J:176118 )

• in the blood

abnormal B cell physiology ( J:176118 )

• marginal zone B cells are resistant to S1P-mediated S1PR1 internalization

• marginal zone B cells exhibit increased chemotaxis response to S1P compared with control cells

• splenic follicular dendritic cells exhibit reduced deposition of phycoerythrin-induced immune complexes compared with control cells

• however, chemotaxis response to CXCL12 and CXCL13 is normal