Phenotypes Associated with This Genotype

Genotype
MGI:5295046

• Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu
• Genetic Background: involves: 129 * BALB/cJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Impaired epithelial stratification in Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu mice

integument

decreased keratinocyte proliferation ( J:177360 )

abnormal epidermal layer morphology ( J:177360 )

• epithelial stratification is disrupted

epidermal hyperplasia ( J:177360 )

thick epidermis ( J:177360 )

cellular

abnormal cell morphology ( J:177360 )

• late passage mouse embryonic fibroblasts are enlarged and flattened compared with wild-type cells

decreased fibroblast proliferation ( J:177360 )

• in mouse embryonic fibroblasts

decreased keratinocyte proliferation ( J:177360 )

early cellular replicative senescence ( J:177360 )

• in mouse embryonic fibroblasts