About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5294943
Allelic
Composition
Pitx1tm1Rsd/Pitx1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pitx1tm1Rsd mutation (0 available); any Pitx1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• 20 of 225 mice exhibit clubfoot, indicating an 8.9% penetrance of clubfoot (J:175799)
• clubfoot is unilateral in 16 of 20 affected mutants, with right and left limbs equally affected (J:175799)
• higher incidence of clubfoot is seen in females compared to males (J:175799)
• 20 of 225 mice exhibit clubfoot, indicating an 8.9% penetrance of clubfoot (J:175799)
• clubfoot is unilateral in 16 of 20 affected mutants, with right and left limbs equally affected (J:175799)
• higher incidence of clubfoot is seen in females compared to males (J:175799)

cardiovascular system
• peroneal artery hypoplasia occurs in the clubfoot limb (J:175799)
• peroneal artery hypoplasia occurs in the clubfoot limb (J:175799)

growth/size/body
• mutants exhibit overall growth impairment (J:175799)
• mutants exhibit overall growth impairment (J:175799)

adipose tissue
• fat volume of the clubfoot limb is increased compared to unaffected limb (J:175799)
• fat volume of the clubfoot limb is increased compared to unaffected limb (J:175799)

muscle
• muscle hypoplasia in the clubfoot limb (J:175799)
• muscle hypoplasia in the clubfoot limb (J:175799)

skeleton
• tibial and fibular bone volumes are reduced in the clubfoot limb (J:175799)
• tibial and fibular bone volumes are reduced in the clubfoot limb (J:175799)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/26/2016
MGI 6.02
The Jackson Laboratory