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Phenotypes Associated with This Genotype
Genotype
MGI:5294943
Allelic
Composition
Pitx1tm1Rsd/Pitx1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pitx1tm1Rsd mutation (0 available); any Pitx1 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• 20 of 225 mice exhibit clubfoot, indicating an 8.9% penetrance of clubfoot
• clubfoot is unilateral in 16 of 20 affected mutants, with right and left limbs equally affected
• higher incidence of clubfoot is seen in females compared to males

cardiovascular system
• peroneal artery hypoplasia occurs in the clubfoot limb

growth/size/body
• mutants exhibit overall growth impairment

adipose tissue
• fat volume of the clubfoot limb is increased compared to unaffected limb

muscle
• muscle hypoplasia in the clubfoot limb

skeleton
• tibial and fibular bone volumes are reduced in the clubfoot limb


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory