Phenotypes Associated with This Genotype

Genotype
MGI:5294421

• Allelic Composition: Tcf7l2^em2Nobr/Tcf7l2⁺
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:175874 )

N • mice exhibit normal energy expenditure

decreased circulating glucose level ( J:175874 )

• in fasting mice fed a high-fat diet

hypoglycemia ( J:175874 )

• intermediate at birth

decreased circulating insulin level ( J:175874 )

• in fasting mice fed a high-fat diet

improved glucose tolerance ( J:175874 )

• on standard chow or when fed a high-fat diet

behavior/neurological

polyphagia ( J:175874 )

decreased locomotor activity ( J:175874 )

growth/size/body

decreased lean body mass ( J:175874 )

decreased body weight ( J:175874 )

• at 1 to 6 weeks of age

adipose tissue

decreased total body fat amount ( J:175874 )