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Phenotypes Associated with This Genotype
Genotype
MGI:5294332
Allelic
Composition
Col11a1cho/Col11a1+
Genetic
Background
involves: C57BL/6Fr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col11a1cho mutation (0 available); any Col11a1 mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• at 3 months, a large number of chondrocyte clusters are present in the superficial layer of articular cartilage in the knee joint unlike in wild-type mice
• at 6 months, mice exhibit a loss of proteoglycan at the knee joint compared with wild-type mice

skeleton
• by 15 months, mice exhibit loss of articular cartilage, misshaped meniscus, and inflammation in the synovial tissues in the knee and tenporomandibular joints unlike in wild-type mice
• cartilage degeneration increases between 9 and 15 months of age
• at 3 months, a large number of chondrocyte clusters are present in the superficial layer of articular cartilage in the knee joint unlike in wild-type mice
• at 6 months, mice exhibit a loss of proteoglycan at the knee joint compared with wild-type mice
• at 3 months, a large number of chondrocyte clusters are present in the superficial layer of articular cartilage in the knee joint unlike in wild-type mice
• tensile stiffness in articular cartilage of the knee joint is moderately reduced compared to in wild-type mice

immune system
• by 15 months, mice exhibit loss of articular cartilage, misshaped meniscus, and inflammation in the synovial tissues in the knee and tenporomandibular joints unlike in wild-type mice
• cartilage degeneration increases between 9 and 15 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
osteoarthritis DOID:8398 J:106282


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory