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Phenotypes Associated with This Genotype
Genotype
MGI:5294332
Allelic
Composition
Col11a1cho/Col11a1+
Genetic
Background
involves: C57BL/6Fr
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• at 3 months, a large number of chondrocyte clusters are present in the superficial layer of articular cartilage in the knee joint unlike in wild-type mice
• at 6 months, mice exhibit a loss of proteoglycan at the knee joint compared with wild-type mice

skeleton
• by 15 months, mice exhibit loss of articular cartilage, misshaped meniscus, and inflammation in the synovial tissues in the knee and tenporomandibular joints unlike in wild-type mice
• cartilage degeneration increases between 9 and 15 months of age
• at 3 months, a large number of chondrocyte clusters are present in the superficial layer of articular cartilage in the knee joint unlike in wild-type mice
• at 6 months, mice exhibit a loss of proteoglycan at the knee joint compared with wild-type mice
• at 3 months, a large number of chondrocyte clusters are present in the superficial layer of articular cartilage in the knee joint unlike in wild-type mice
• tensile stiffness in articular cartilage of the knee joint is moderately reduced compared to in wild-type mice

immune system
• by 15 months, mice exhibit loss of articular cartilage, misshaped meniscus, and inflammation in the synovial tissues in the knee and tenporomandibular joints unlike in wild-type mice
• cartilage degeneration increases between 9 and 15 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
osteoarthritis DOID:8398 OMIM:140600
OMIM:165720
OMIM:607850
OMIM:612400
J:106282


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory