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Phenotypes Associated with This Genotype
Genotype
MGI:5293682
Allelic
Composition
Noa1tm1Tze/Noa1tm1Tze
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Noa1tm1Tze mutation (0 available); any Noa1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no viable embryos are observed at E10.5

cellular
• embryos exhibit abnormal mitochondria with swollen cristae
• primary fibroblasts grown under nutrient restriction exhibit reduced viability and cellular ATP compared with similarly treated wild-type cells
• in E9.5 embryos
• cells exhibit resistance to straurosporine-induced apoptosis compared with similarly treated wild-type cells
• E10.5 embryos are necrotic
• mitochondrial protein synthesis is compromised compared to in wild-type cells
• digitonin-permeabilized primary fibroblasts exhibit severe reduction in complex I, III, and IV-dependent oxygen consumption, indicating a global OXPHOS defect, compared with similarly treated wild-type mice

embryo
• E10.5 embryos are necrotic
• at E9.5, only 9 somites are observed
• all three trophoblast layers, including the trophoblast giant cell layer, are reduced compared to in wild-type mice

growth/size/body
• at E9.5, only 9 somites are observed


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory