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Phenotypes Associated with This Genotype
Genotype
MGI:5293236
Allelic
Composition
Slc13a5tm1.2Helf/Slc13a5tm1.2Helf
Genetic
Background
B6.Cg-Slc13a5tm1.2Helf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc13a5tm1.2Helf mutation (0 available); any Slc13a5 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• increase in the proportion of lean body mass by 11% at 8 months of age
• body weight is 10% lower on a regular chow diet at 4 weeks of age compared to wild-type mice
• at 3 months of age
• decreased weight gain on a high fat diet compared to wild-type mice

adipose tissue
• the proportion of fat mass to body weight is markedly reduced in mice on a high fat diet
• fat mass is reduced by 45% in chow fed mice at 8 months of age

homeostasis/metabolism
• plasma lactate concentrations are reduced in mice on a high fat diet
• on a normal chow or high fat diet
• decreased weight gain on a high fat diet compared to wild-type mice
• endogenous glucose production is reduced
• basal plasma glucose is reduced
• basal plasma insulin is reduced
• glycemic excursion and plasma insulin excursion are reduced in intraperitoneal glucose tolerance tests
• preserved insulin sensitivity at 8 months of age compared to age matched wild-type controls
• decrease in hepatic and muscle diacylglycerol concentrations
• rates of nonoxidative glucose metabolism tend to be increased in mice on a high fat diet and are significantly higher in older mice
• whole body glucose metabolism is increased during an hyperinsulinemic-euglycemic clamp

liver/biliary system
• markedly reduced liver lipid content in mice on a high fat diet
• decrease in hepatic diacylglycerol concentrations
• mitochondrial density is increased in hepatocytes
• show a 20% reduction in hepatic citrate uptake
• decrease in lipid generation
• analysis indicates hepatic lipid peroxidation is increased by 62%
• oxygen consumption is increased in liver homogenates
• lipid oxidation is increased and citrate uptake is reduced in primary hepatocytes
• hepatic ATP concentration is reduced

behavior/neurological
• increase in locomotor activity during the first 3?4 hr of food ingestion

muscle
• decrease in muscle diacylglycerol concentrations
• peripheral glucose uptake by the gastrocnemius muscle is increased

cellular
• mitochondrial density is increased in hepatocytes
• peripheral glucose uptake by the gastrocnemius muscle is increased


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory