Phenotypes Associated with This Genotype

Genotype
MGI:5292552

• Allelic Composition: Nf1^tm1Fcr/Nf1⁺; Tg(GFAP-cre)#Gtm/0
• Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Nf1^tm1Fcr/Nf1⁺ Tg(GFAP-cre)#Gtm/0 mice develop prechiasmatic optic nerve and chiasmal gliomas

nervous system

abnormal neuron proliferation ( J:176586 )

• cell proliferation in the optic nerve is increased compared to in wild-type mice

increased glioma incidence ( J:176586 )

• optic gliomas

abnormal optic nerve morphology ( J:176586 )

• kinking of the prechiasmatic optic nerves

increased optic chiasm size ( J:176586 )

• enlarged

neoplasm

increased glioma incidence ( J:176586 )

• optic gliomas

vision/eye

abnormal optic nerve morphology ( J:176586 )

• kinking of the prechiasmatic optic nerves

increased optic chiasm size ( J:176586 )

• enlarged

cellular

abnormal neuron proliferation ( J:176586 )

• cell proliferation in the optic nerve is increased compared to in wild-type mice