Mouse Genome Informatics
involves: 129P2/OlaHsd * 129/Sv * C57BL/6 * FVB/N
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants show a lower AMPA to NMDA glutamate receptor ratio in hippocampal CA1 pyramidal neurons at 2 weeks of age, but not at 6-7 weeks of age
• mutants show a lower AMPA to NMDA current ratio in hippocampal CA1 neurons at 2 weeks of age, but not at 6-7 weeks of age, indicating that glutamatergic neuerotransmission at synapses of hippocampal CA1 pyramidal neurons is altered during early postnatal development but not in adulthood
• induction of NMDA receptor-dependent long-term potentiation following a low-frequency pairing protocol, but not theta-burst pairing protocol, is increased at 2 weeks of age but not in adulthood
• however, presynaptic paired-pulse potentiation in the hippocampal CA1 neurons and intrinsic postsynaptic excitability are unchanged in mutants and no differences in short- and long-term depression are seen
• miniature currents are altered in mutants; AMPA mEPSCs are reduced in amplitude but not in frequency while NMDA mEPSCs are increased in amplitude

Mouse Models of Human Disease
Fragile X Mental Retardation Syndrome 300624 J:176553