Analysis Tools
liver/biliary system
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• inflammatory infiltrates, comprised of numerous clusters of lymphocytes and Kupffer cells, seen accompanying partial resolution of steatosis
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• at 15 months of age livers contain distinct nodular lesions with slightly different color from the surrounding hepatic parenchyma
• nodules, consisting of eosinophilic and/or basophilic hepatocytes with focal or diffuse dysplastic changes and increased cell density, almost completely replace the liver parenchyma
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• at 10 weeks and 15 months of age
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• numerous lipid vacuoles of varying sizes are seen within the cytoplasm of zones 2 and 3 hepatocytes
• steatotic hepatocytes either lack or show diminished numbers of peroxisomes while hepatocytes immediately adjacent to fatty areas have higher amounts of peroxisomes
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• show microvesicular steatosis involving most of the hepatic lobule with sparing of periportal hepatocytes at 8 weeks of age
• striking zonal pattern of steatosis persists at 3 and 4 months of age
• at 6 months of age, livers display areas of steatosis along with areas with complete resolution of the steatosis
• numerous lipid vacuoles of varying sizes are seen within the cytoplasm of zones 2 and 3 hepatocytes
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• occur in multiple areas intermingled with dysplastic foci at around 1 year of age
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homeostasis/metabolism
neoplasm
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• occur in multiple areas intermingled with dysplastic foci at around 1 year of age
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reproductive system
growth/size/body
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• at 6 weeks of age
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• at 10 weeks and 15 months of age
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immune system
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• inflammatory infiltrates, comprised of numerous clusters of lymphocytes and Kupffer cells, seen accompanying partial resolution of steatosis
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