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Phenotypes Associated with This Genotype
Genotype
MGI:5285825
Allelic
Composition		 Lgr4tm1.1Knis/Lgr4tm1.1Knis
Lgr5tm2.1Cle/Lgr5tm2.1Cle
Tg(Vil1-cre/ERT2)23Syr/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr4tm1.1Knis mutation (0 available); any Lgr4 mutation (94 available)
Lgr5tm2.1Cle mutation (0 available); any Lgr5 mutation (57 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestine physiology ( J:174842 )
• generated intestinal organoids degrade after 2 days of tamoxifen treatment
• however, organoid survival is rescued by retroviral expression of LGR5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory