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Phenotypes Associated with This Genotype
Genotype
MGI:5285545
Allelic
Composition		 Ryr2tm1.1Swch/Ryr2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2tm1.1Swch mutation (0 available); any Ryr2 mutation (325 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
ventricular tachycardia ( J:174541 )
• mice treated with caffeine and epinephrine exhibit increased ventricular compared with similarly treated wild-type mice

homeostasis/metabolism
increased physiological sensitivity to xenobiotic ( J:174541 )
• mice treated with caffeine and epinephrine exhibit increased ventricular compared with similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory