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Phenotypes Associated with This Genotype
Genotype
MGI:5285183
Allelic
Composition
Gnastm1Gwa/Gnas+
Genetic
Background
involves: 129S/SvEv * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnastm1Gwa mutation (0 available); any Gnas mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Subcutaneous ossifications in Gnastm1Gwa/Gnas+ mice

growth/size/body

integument
• mutants, regardless of whether the allele is maternally or paternally inherited, develop extensive and progressive subcutaneous ossifications
• females exhibit fewer ossifications at all times examined than males
• mutants, regardless of whether the allele is maternally or paternally inherited, develop extensive and progressive subcutaneous ossifications, with rare lesions in the dermis and subcutis at 3 months but very common at 12 months
• 12 month old mutants exhibit erythemateous and mildly erosive footpad lesions
• occasionally mice exhibit nodular subcutaneous ear lesions, always near the site of ear tags that are not seen in wild-type mice, indicating that areas of pressure and trauma develop ossifications
• at 12 months of age, lesions are more severe in males than females for both maternally and paternally inherited alleles

skeleton
• heterotopic bone formation is seen in the skin and is often associated with a dense eosinophilic osteoid-like matrix in the dermis and perifollicular areas
• subcutaneous ossifications are mineralized and express osteoblast markers and appear to originate near the hair follicle
• males have more severe and widespread heterotopic bone in the subcutaneous tissue than female mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory