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Phenotypes Associated with This Genotype
Genotype
MGI:5141747
Allelic
Composition
Tg(UPII-SV40T)29Xrw/0
Genetic
Background
involves: FVB/N
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phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• mutants succumb to bladder cancer at 5 months of age
• all mice examined at 1-2 months of age exhibit only bladder carcinoma in situ (CIS) changes, but by 5 months of age, invasive and metastatic transitional cell carcinoma (TCC) is seen
• mutants develop a palpable abdominal tumor at 5 months of age, with histology identifying it as a poorly differentiated transitional cell carcinoma (TCC)

tumorigenesis
• mutants succumb to bladder cancer at 5 months of age
• all mice examined at 1-2 months of age exhibit only bladder carcinoma in situ (CIS) changes, but by 5 months of age, invasive and metastatic transitional cell carcinoma (TCC) is seen
• mutants develop a palpable abdominal tumor at 5 months of age, with histology identifying it as a poorly differentiated transitional cell carcinoma (TCC)
• micrometastases are seen in the pelvic lymph nodes and lingular lobe of the liver

Mouse Models of Human Disease
OMIM ID Ref(s)
Bladder Cancer 109800 J:56305


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory