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Phenotypes Associated with This Genotype
Genotype
MGI:5141005
Allelic
Composition
Cdc42tm1.1Yizh/Cdc42+
Nkx2-5tm1Siz/Nkx2-5+
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc42tm1.1Yizh mutation (0 available); any Cdc42 mutation (43 available)
Nkx2-5tm1Siz mutation (0 available); any Nkx2-5 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at 4 weeks of age
• at 4 weeks of age, mice exhibit decreased cardiac stroke volume compared with wild-type mice and single heterozygotes
• at 4 weeks of age, mice exhibit decreased cardiac function (reduced left ventricle ejection fraction, fractional shortening of the ventricular chamber, volume of ejected blood with each heart beat, and cardiac output) compared with wild-type mice or single heterozygotes
• mice exhibit prolonged QT and QTc intervals compared with wild-type mice

muscle
• at 4 weeks of age, mice exhibit decreased cardiac function (reduced left ventricle ejection fraction, fractional shortening of the ventricular chamber, volume of ejected blood with each heart beat, and cardiac output) compared with wild-type mice or single heterozygotes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory