Phenotypes Associated with This Genotype

Genotype
MGI:5140011

• Allelic Composition: A^y/A^y
• Genetic Background: 101-A^y

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality ( J:174504 )

embryonic lethality at implantation, complete penetrance ( J:174504 )

• putative homozygous embryos appear as small masses of vacuolated cells in decidual crypts at the time normal embryos are implanting; the abnormal embryo is resorbed within 36 hours

• Background Sensitivity: the genotype of the mother, with or without A^y, determines if a homozygous embryo dies at the initial stage of implantation or after the process begins

cellular

maternal effect ( J:174504 )

• introducing homozygous A^y embryos into the uterus of a wild-type mouse delays embryonic death until after implantation begins

• there are approximately twice the number of cells, development of a small ectoplacental cone and Reichert's membrane, and disintegration of the decidual epithelium characteristic of an advanced implantation site