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Phenotypes Associated with This Genotype
Genotype
MGI:5086118
Allelic
Composition
Amelxtm1Kul/Amelxtm1Kul
Tg(AMELX*P70T)2Gibs/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amelxtm1Kul mutation (1 available); any Amelx mutation (17 available)
Tg(AMELX*P70T)2Gibs mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells

neoplasm
• molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells
• tumor is composed of benign, eosinophilic, polygonal-shaped cells with intercellular bridges
• calcification is not obvious in these tumors

craniofacial
• molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells

growth/size/body
• molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Amelogenesis Imperfecta, Type IE; AI1E 301200 J:122914


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory