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Phenotypes Associated with This Genotype
Genotype
MGI:5086005
Allelic
Composition
Amer1tm1.2Nbar/Y
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

homeostasis/metabolism

cardiovascular system
• dramatic overgrowth

growth/size/body

renal/urinary system
• kidneys may display agenesis or over growth, with both conditions often seen in the same animal
• unilateral or bilateral renal agenesis is seen in 64% of mice
• kidneys that do form have an expanded population of mesenchymal progenitor cells
• the Wolffian duct remains detached from the ureteric bud at E13.5 in some mice
• absence of ureteric bud derived structures at E13.5 in some mice
• expression analysis indicates that the metanephric mesenchyme is specified but fails to condense and undergo epithelialization
• widespread apoptosis is seen in many mice
• kidneys that do form are significantly enlarged
• absence of ureteric bud derived structures at E13.5 in some mice

embryo
• widespread apoptosis is seen in many mice
• the Wolffian duct remains detached from the ureteric bud at E13.5 in some mice

skeleton
• dramatic bone overgrowth
• malformation of the postnatal suture
• enlarged cranial vault
• abnormally distant ossification fronts in the perinatal cranial vault
• discontinuous cortical bone layer at E15.5
• enlarged and bowed
• enlarged and bowed
• asymmetrical distribution of ossification centers
• massive increases in mineralized matrix
• decreased mineralization of the trabecular area in long bones perinatally
• massive increases in mineralized matrix in the compact bone
• deficiency in endochondral bone ossification
• delayed ossification of the long bones at E14.5
• discontinuous cortical bone layer in long bones at E15.5
• deficiency in intramembranous bone ossification
• abnormally distant ossification fronts in the perinatal cranial vault

adipose tissue
• hypoplastic adipose tissue

hematopoietic system

immune system

craniofacial
• malformation of the postnatal suture
• enlarged cranial vault
• abnormally distant ossification fronts in the perinatal cranial vault

limbs/digits/tail
• enlarged and bowed
• enlarged and bowed

cellular
• widespread apoptosis is seen in many mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Osteopathia Striata with Cranial Sclerosis; OSCS 300373 J:173242


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory