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Phenotypes Associated with This Genotype
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic2tm1Jaru mutation (1 available); any Zic2 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• mice exhibit normal responses in the light-dark box test, marble burying test, elevated plus maze test, forced swimming test, grip strength test, wire hanging test, footprint test, and rotarod test
• in a Morris water maze, mice exhibit increased latency to training and reverse compared with wild-type mice
• in a Y maze, mice exhibit an increase in number of entries and a decrease in alternation compared with wild-type mice
• mice are often the losers in a social dominance test unlike wild-type mice
• in an open field test
• in a home cage

nervous system
• most notable in the anterior horn region
• with reduction in the mass of the septum
• in 6 of 8 mice, the medial protrusion of the amygdala in the coronal sections is blunted compared to in wild-type mice
• the position and shape of the medial structure rostral to the hippocampus were narrower than in wild-type mice
• slight thinner than in wild-type mice
• the number of cholinergic neurons are decreased in the basal forebrain compared to in wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
schizophrenia DOID:5419 OMIM:181500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory