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Phenotypes Associated with This Genotype
Genotype
MGI:5085985
Allelic
Composition
Zic2tm1Jaru/Zic2+
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic2tm1Jaru mutation (1 available); any Zic2 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal responses in the light-dark box test, marble burying test, elevated plus maze test, forced swimming test, grip strength test, wire hanging test, footprint test, and rotarod test (J:174352)
• mice exhibit normal responses in the light-dark box test, marble burying test, elevated plus maze test, forced swimming test, grip strength test, wire hanging test, footprint test, and rotarod test (J:174352)
• mice are often the losers in a social dominance test unlike wild-type mice (J:174352)
• mice are often the losers in a social dominance test unlike wild-type mice (J:174352)
• slight (J:174352)
• slight (J:174352)
• in a Morris water maze, mice exhibit increased latency to training and reverse compared with wild-type mice (J:174352)
• in a Morris water maze, mice exhibit increased latency to training and reverse compared with wild-type mice (J:174352)
• in a Y maze, mice exhibit an increase in number of entries and a decrease in alternation compared with wild-type mice (J:174352)
• in a Y maze, mice exhibit an increase in number of entries and a decrease in alternation compared with wild-type mice (J:174352)
• in an open field test (J:174352)
• in an open field test (J:174352)
• in a home cage (J:174352)
• in a home cage (J:174352)

nervous system
• most notable in the anterior horn region (J:174352)
• with reduction in the mass of the septum (J:174352)
• most notable in the anterior horn region (J:174352)
• with reduction in the mass of the septum (J:174352)
• in 6 of 8 mice, the medial protrusion of the amygdala in the coronal sections is blunted compared to in wild-type mice (J:174352)
• in 6 of 8 mice, the medial protrusion of the amygdala in the coronal sections is blunted compared to in wild-type mice (J:174352)
• the position and shape of the medial structure rostral to the hippocampus were narrower than in wild-type mice (J:174352)
• the position and shape of the medial structure rostral to the hippocampus were narrower than in wild-type mice (J:174352)
• slight thinner than in wild-type mice (J:174352)
• slight thinner than in wild-type mice (J:174352)
• slight (J:174352)
• slight (J:174352)
• the number of cholinergic neurons are decreased in the basal forebrain compared to in wild-type mice (J:174352)
• the number of cholinergic neurons are decreased in the basal forebrain compared to in wild-type mice (J:174352)

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:174352


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory