Mouse Genome Informatics
ht
    Zic2tm1Jaru/Zic2+
involves: 129S4/SvJae * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
N
• mice exhibit normal responses in the light-dark box test, marble burying test, elevated plus maze test, forced swimming test, grip strength test, wire hanging test, footprint test, and rotarod test (J:174352)
• mice are often the losers in a social dominance test unlike wild-type mice
• in a Morris water maze, mice exhibit increased latency to training and reverse compared with wild-type mice
• in a Y maze, mice exhibit an increase in number of entries and a decrease in alternation compared with wild-type mice
• in an open field test
• in a home cage

nervous system
• most notable in the anterior horn region
• with reduction in the mass of the septum
• in 6 of 8 mice, the medial protrusion of the amygdala in the coronal sections is blunted compared to in wild-type mice
• the position and shape of the medial structure rostral to the hippocampus were narrower than in wild-type mice
• slight thinner than in wild-type mice
• the number of cholinergic neurons are decreased in the basal forebrain compared to in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Schizophrenia; SCZD 181500 J:174352