Phenotypes Associated with This Genotype

Genotype
MGI:5085985

• Allelic Composition: Zic2^tm1Jaru/Zic2⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:174352 )

N • mice exhibit normal responses in the light-dark box test, marble burying test, elevated plus maze test, forced swimming test, grip strength test, wire hanging test, footprint test, and rotarod test

impaired contextual conditioning behavior ( J:174352 )

impaired cued conditioning behavior ( J:174352 )

• slight

abnormal spatial learning ( J:174352 )

• in a Morris water maze, mice exhibit increased latency to training and reverse compared with wild-type mice

abnormal spatial working memory ( J:174352 )

• in a Y maze, mice exhibit an increase in number of entries and a decrease in alternation compared with wild-type mice

decreased aggression towards mice ( J:174352 )

• mice are often the losers in a social dominance test unlike wild-type mice

decreased locomotor activity ( J:174352 )

• in a home cage

hyperactivity ( J:174352 )

• in an open field test

nervous system

decreased brain size ( J:174352 )

enlarged lateral ventricles ( J:174352 )

• most notable in the anterior horn region

• with reduction in the mass of the septum

abnormal amygdala morphology ( J:174352 )

• in 6 of 8 mice, the medial protrusion of the amygdala in the coronal sections is blunted compared to in wild-type mice

abnormal cerebral hemisphere morphology ( J:174352 )

• the position and shape of the medial structure rostral to the hippocampus were narrower than in wild-type mice

decreased corpus callosum size ( J:174352 )

• slight thinner than in wild-type mice

thin cerebral cortex ( J:174352 )

• slight

decreased neuron number ( J:174352 )

• the number of cholinergic neurons are decreased in the basal forebrain compared to in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:174352