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Phenotypes Associated with This Genotype
Genotype
MGI:5085866
Allelic
Composition
Nlrp6tm1Flv/Nlrp6tm1Flv
Genetic
Background
B6.Cg-Nlrp6tm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp6tm1Flv mutation (0 available); any Nlrp6 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• increased sensitivity to and pathology of oral rotavirus inoculation
• elevated viral load in ileum after oral rotavirus inoculation of 8 day old pups

immune system
• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice
• mice transmit increased susceptibility to DSS-induced colitis to co-housed wild-type mice
• transmission of increased susceptibility to DSS-induced colitis to co-housed Ccl5-deficient mice is not as severe as to co-housed wild-type mice
• mice exhibit increased CD45+ cells in the colons compared with wild-type mice
• mice exhibit increased B220+ cells from the lamina propria compared with wild-type mice
• in untreated mice
• in untreated mice
• in untreated and DSS-treated mice
• in untreated mice
• in colonic explants form untreated and DSS-treated mice
• increased sensitivity to and pathology of oral rotavirus inoculation
• elevated viral load in ileum after oral rotavirus inoculation of 8 day old pups

digestive/alimentary system
• colonic crypt hyperplasia in untreated mice
• increased occurrence after oral rotavirus inoculation of 8 day old pups
• mice and co-housed wild-type mice exhibit expanded bacterial phylotypes compared with wild-type mice
• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice
• mice transmit increased susceptibility to DSS-induced colitis to co-housed wild-type mice
• transmission of increased susceptibility to DSS-induced colitis to co-housed Ccl5-deficient mice is not as severe as to co-housed wild-type mice

endocrine/exocrine glands
• colonic crypt hyperplasia in untreated mice

hematopoietic system
• mice exhibit increased CD45+ cells in the colons compared with wild-type mice
• mice exhibit increased B220+ cells from the lamina propria compared with wild-type mice
• in untreated mice
• in untreated mice

homeostasis/metabolism
• in untreated and DSS-treated mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory