Phenotypes Associated with This Genotype

Genotype
MGI:5085866

• Allelic Composition: Nlrp6^tm1Flv/Nlrp6^tm1Flv
• Genetic Background: B6.Cg-Nlrp6^tm1Flv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:173245 )

• in DSS-treated mice

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:243487 )

• increased sensitivity to and pathology of oral rotavirus inoculation

• elevated viral load in ileum after oral rotavirus inoculation of 8 day old pups

immune system

increased susceptibility to induced colitis ( J:173245 )

• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice

• mice transmit increased susceptibility to DSS-induced colitis to co-housed wild-type mice

• transmission of increased susceptibility to DSS-induced colitis to co-housed Ccl5-deficient mice is not as severe as to co-housed wild-type mice

increased leukocyte cell number ( J:173245 )

• mice exhibit increased CD45+ cells in the colons compared with wild-type mice

increased B cell number ( J:173245 )

• mice exhibit increased B220+ cells from the lamina propria compared with wild-type mice

increased IgA level ( J:173245 )

• in untreated mice

increased IgG2c level ( J:173245 )

• in untreated mice

decreased circulating interleukin-18 level ( J:173245 )

• in untreated and DSS-treated mice

enlarged Peyer's patches ( J:173245 )

• in untreated mice

decreased interleukin-18 secretion ( J:173245 )

• in colonic explants form untreated and DSS-treated mice

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:243487 )

• increased sensitivity to and pathology of oral rotavirus inoculation

• elevated viral load in ileum after oral rotavirus inoculation of 8 day old pups

digestive/alimentary system

abnormal large intestine crypts of Lieberkuhn morphology ( J:173245 )

• colonic crypt hyperplasia in untreated mice

diarrhea ( J:243487 )

• increased occurrence after oral rotavirus inoculation of 8 day old pups

abnormal gut flora balance ( J:173245 )

• mice and co-housed wild-type mice exhibit expanded bacterial phylotypes compared with wild-type mice

increased susceptibility to induced colitis ( J:173245 )

• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice

• mice transmit increased susceptibility to DSS-induced colitis to co-housed wild-type mice

• transmission of increased susceptibility to DSS-induced colitis to co-housed Ccl5-deficient mice is not as severe as to co-housed wild-type mice

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:173245 )

• colonic crypt hyperplasia in untreated mice

hematopoietic system

increased leukocyte cell number ( J:173245 )

• mice exhibit increased CD45+ cells in the colons compared with wild-type mice

increased B cell number ( J:173245 )

• mice exhibit increased B220+ cells from the lamina propria compared with wild-type mice

increased IgA level ( J:173245 )

• in untreated mice

increased IgG2c level ( J:173245 )

• in untreated mice

homeostasis/metabolism

decreased circulating interleukin-18 level ( J:173245 )

• in untreated and DSS-treated mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:173245 )

• in DSS-treated mice