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Phenotypes Associated with This Genotype
Genotype
MGI:5056394
Allelic
Composition
Tg(Prnp-ATN1)150Dbo/?
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice begin dying as early as 10 weeks, many are dead by 50 weeks

behavior/neurological
• beginning at 1-2 months
• involuntary tremors beginning at 1-2 months
• progressive ataxia beginning at 1-2 months
• loss of limb coordination beginning at 1-2 months
• beginning at 1-2 months
• decreased breeding efficiency
• seizures are observed in some animals

nervous system
• seizures are observed in some animals
• inclusion bodies observed in the dentate nucleus of the cerebellum of 12 month old mice
• a few inclusions are observed in the heart

Mouse Models of Human Disease
OMIM ID Ref(s)
Dentatorubral-Pallidoluysian Atrophy; DRPLA 125370 J:70362


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory