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Phenotypes Associated with This Genotype
Genotype
MGI:5052381
Allelic
Composition
Tg(HTT*/EGFP)150Nn/0
Genetic
Background
involves: C57BL/6 * DBA/2
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 32 weeks
• all die by 58 weeks of age

nervous system
• progression of neuropathology is less rapid compared to mice carrying Tg(HTT*/EGFP)190Nn
• dense EGFP positive aggregates are detected mostly in the cytoplasm at 35 weeks of age
• dense EGFP positive aggregates are detected mostly in the cytoplasm at 35 weeks of age
• dense EGFP positive aggregates are detected mostly in the cytoplasm at 35 weeks of age
• a few dense EGFP positive aggregates are detected in the nucleus but most are localized to the cytoplasm in the striatum, cortex and hippocampus at 35 weeks of age
• aggregates appear in both the nucleus and cytoplasm at 4 weeks of age but nuclear aggregates gradually lose EGFP fluorescence with age

behavior/neurological
• chorea-like movements
• show irregular, jerky involuntary head movements at about 16 weeks of age
• rare
• fine tremor with onset at about 9-11 weeks of age
• progressive development of an ataxic gait that is severe and interferes with walking by 30 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Huntington's disease DOID:12858 OMIM:143100
J:174269


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory