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Phenotypes Associated with This Genotype
Genotype
MGI:5052373
Allelic
Composition		 Plxnd1tm1Ddg/Plxnd1tm1.1Tmj
Tg(CAG-cre/Esr1*)1Egwa/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnd1tm1.1Tmj mutation (1 available); any Plxnd1 mutation (86 available)
Plxnd1tm1Ddg mutation (0 available); any Plxnd1 mutation (86 available)
Tg(CAG-cre/Esr1*)1Egwa mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Increase in extraretinal vascular outgrowth in ischemic Plxnd1tm1.1Tmj/Plxnd1tm1Ddg Tg(CAG-cre/Esr1*)1Egwa/0 retinas

vision/eye
abnormal induced retina neovascularization ( J:173943 )
• tamoxifen-treated mice exhibit increased extraretinal vascular outgrowth in ischemic retinas compared with control mice

cardiovascular system
abnormal induced retina neovascularization ( J:173943 )
• tamoxifen-treated mice exhibit increased extraretinal vascular outgrowth in ischemic retinas compared with control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory