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Phenotypes Associated with This Genotype
Genotype
MGI:5052367
Allelic
Composition
Tg(JPH3-GFP,-JPH3*)GXwy/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(JPH3-GFP,-JPH3*)GXwy mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• unlike in mice carrying Tg(JPH3*)CXwy no signs of neurodegeneration are detected at 12 months of age
• diffuse accumulation of polyQ nuclear inclusions are detected in the striatum
• progressive formation of polyQ nuclear inclusions between 6 and 14 months of age
• progressive formation of polyQ nuclear inclusions between 6 and 14 months of age
• progressive formation of polyQ nuclear inclusions between 6 and 14 months of age
• inclusions are particularly abundant in the cortex and hippocampus with diffuse accumulation also detected in the striatum

behavior/neurological
• impaired motor learning in a rotarod assay at 12 months of age
• at 12 months of age in a rotarod assay

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Huntington disease-like 2 DOID:0090104 OMIM:606438
J:174267


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/13/2017
MGI 6.11
The Jackson Laboratory