Mouse Genome Informatics
tg
    Tg(JPH3-GFP,-JPH3*)GXwy/0
involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
N
• unlike in mice carrying Tg(JPH3*)CXwy no signs of neurodegeneration are detected at 12 months of age (J:174267)
• diffuse accumulation of polyQ nuclear inclusions are detected in the striatum
• progressive formation of polyQ nuclear inclusions between 6 and 14 months of age
• progressive formation of polyQ nuclear inclusions between 6 and 14 months of age
• progressive formation of polyQ nuclear inclusions between 6 and 14 months of age
• inclusions are particularly abundant in the cortex and hippocampus with diffuse accumulation also detected in the striatum

behavior/neurological
• impaired motor learning in a rotarod assay at 12 months of age
• at 12 months of age in a rotarod assay

Mouse Models of Human Disease
OMIM IDRef(s)
Huntington Disease-Like 2; HDL2 606438 J:174267