Mouse Genome Informatics
cx
    Cnr1tm1Map/Cnr1tm1Map
Tg(HD82Gln)81Gschi/0

involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• reduced lifespan compared to wild-type controls
• however lifespan is similar to transgenic mice wild-type for Cnr1

nervous system
• increase in the density of ubiquitin positive aggregates in the striatum compared to transgenic mice wild-type for Cnr1

behavior/neurological
• reduced latency to fall and an increased number of falls in a rotarod assay
• motor performance is worse than in transgenic mice wild-type for Cnr1

growth/size/body
• fail to gain weight after 16 weeks of age
• fail to gain weight after 16 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Huntington Disease; HD 143100 J:172874