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Phenotypes Associated with This Genotype
Genotype
MGI:5052307
Allelic
Composition
Cnr1tm1Map/Cnr1tm1Map
Tg(HD82Gln)81Gschi/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnr1tm1Map mutation (0 available); any Cnr1 mutation (12 available)
Tg(HD82Gln)81Gschi mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• reduced lifespan compared to wild-type controls
• however lifespan is similar to transgenic mice wild-type for Cnr1

nervous system
• increase in the density of ubiquitin positive aggregates in the striatum compared to transgenic mice wild-type for Cnr1

behavior/neurological
• reduced latency to fall and an increased number of falls in a rotarod assay
• motor performance is worse than in transgenic mice wild-type for Cnr1

growth/size/body
• fail to gain weight after 16 weeks of age
• fail to gain weight after 16 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Huntington's disease DOID:12858 OMIM:143100
J:172874


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory