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Phenotypes Associated with This Genotype
Genotype
MGI:5052265
Allelic
Composition		 Lcn2tm1Mrgr/Lcn2tm1Mrgr
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcn2tm1Mrgr mutation (0 available); any Lcn2 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:173490 )
• bone marrow-derived mast cells exhibit reduced apoptosis induced by cytokine deprivation compared with wild-type cells
• Background Sensitivity: mice on a mixed 129 and C57BL/6 background exhibit less of a reduction in mast cell apoptosis induced by cytokine deprivation compared with mice on a 129 or C57BL/6 congenic background

hematopoietic system
abnormal mast cell physiology ( J:173490 )
• bone marrow-derived mast cells exhibit reduced apoptosis induced by cytokine deprivation compared with wild-type cells
• Background Sensitivity: mice on a mixed 129 and C57BL/6 background exhibit less of a reduction in mast cell apoptosis induced by cytokine deprivation compared with mice on a 129 or C57BL/6 congenic background

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory