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Phenotypes Associated with This Genotype
Genotype
MGI:5052112
Allelic
Composition
Tg(Mapt-MAPT*)#Hanr/0
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• plaque like structures are detected but no amyloid beta protein is detected in these plaques
• are detected in the cortex, hippocampus and brainstem at 6 months of age and to a greater extent at 9 months of age
• at 10 months of age
• in the cortex, hippocampus and brainstem at 6 months of age and to a greater extent at 9 months of age
• able to induce short term potentiation but unable to maintain it
• at 60 ms inter-stimulus intervals

behavior/neurological
N
• do not display any gross motor defects
• at 6-7 months of age, perform worse in an 8 arm maze over 5 days of training
• deficits remain at 9 months of age
• at 6-7 months of age, perform worse in an 8 arm maze over 5 days of training
• deficits remain at 9 months of age
• defecate and urinate excessively in an 8 arm maze suggesting an increase in anxiety

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:137947


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory