Mouse Genome Informatics
tg
    Tg(Mapt-MAPT*)#Hanr/0
involves: BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• plaque like structures are detected but no amyloid beta protein is detected in these plaques
• are detected in the cortex, hippocampus and brainstem at 6 months of age and to a greater extent at 9 months of age
• at 10 months of age
• in the cortex, hippocampus and brainstem at 6 months of age and to a greater extent at 9 months of age
• able to induce short term potentiation but unable to maintain it
• at 60 ms inter-stimulus intervals

behavior/neurological
N
• do not display any gross motor defects (J:137947)
• defecate and urinate excessively in an 8 arm maze suggesting an increase in anxiety
• at 6-7 months of age, perform worse in an 8 arm maze over 5 days of training
• deficits remain at 9 months of age
• at 6-7 months of age, perform worse in an 8 arm maze over 5 days of training
• deficits remain at 9 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:137947