Mouse Genome Informatics
hm
    Mcoln1tm1Asoy/Mcoln1tm1Asoy
involves: 129 * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size
• growth and survival are normal to 6 months of age
• growth retardation after 6 months

behavior/neurological
• after 6 months

digestive/alimentary system
• parietal cells at 4 weeks of age are grossly enlarged
• numerous vacuoles are present at 4 weeks
• lysosomes are enlarged
• poorly developed intracellular canaliculi network after histamine stimulation
• increased stomach mass
• basal stomach acid content at 16 weeks of age is significantly reduced

homeostasis/metabolism
• elevated serum gastrin levels

Mouse Models of Human Disease
OMIM IDRef(s)
Mucolipidosis IV 252650 J:173516