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Phenotypes Associated with This Genotype
Genotype
MGI:5014820
Allelic
Composition
Slc25a37tm1.1Kapl/Slc25a37tm1.2Kapl
Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc25a37tm1.1Kapl mutation (0 available); any Slc25a37 mutation (9 available)
Slc25a37tm1.2Kapl mutation (0 available); any Slc25a37 mutation (9 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• viability is normal

homeostasis/metabolism
N
• iron and heme metabolism is normal unless fed delta aminolevulinic acid
• increased protoporphyrin IX in liver, plasma, and red blood cells when fed delta aminolevulinic acid

liver/biliary system
• when fed delta aminolevulinic acid
• increased collagen deposition when fed delta aminolevulinic acid, also occurs to a to lesser extent in heterozygotes
• bile accumulation occurs when fed delta aminolevulinic acid

hematopoietic system
• slightly enlarged when fed delta aminolevulinic acid

immune system
• slightly enlarged when fed delta aminolevulinic acid

growth/size/body
• when fed delta aminolevulinic acid
• slightly enlarged when fed delta aminolevulinic acid


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory