About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5014212
Allelic
Composition
Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• induction increases microglia numbers by about 17%
• following induction, local microglial activation in the substantia nigra and striatum but not in the cortex
• following induction of transgene expression surviving tyrosine hydroxylase positive cells in mesencephalic cultures prepared from E14 embryos show significant loss of neurite processes
• induction of transgene expression results in significant loss of tyrosine hydroxylase positive cells in mesencephalic cultures prepared from E14 embryos
• a 2 week induction period results in a 40% loss of dopaminergic neurons in the substantia nigra
• loss of dopaminergic neurons is prevented by deprenyl co-treatment
• removal of doxycycline from the feed does not reverse cell loss
• irreversible dopaminergic substantia nigra neurodegeneration following induction of transgene expression
• following induction elevated levels of H2O2 are found in the media of cultures of mesencephalic cultures
• H2O2 levels are elevated in isolated ST dopaminergic synaptosomes following induction of transgene expression
• elevated levels of mitochondrial O2- levels in dopaminergic neurons following induction

behavior/neurological
• locomotor activity is reduced following 2 weeks of doxycycline treatment

hematopoietic system
• induction increases microglia numbers by about 17%
• following induction, local microglial activation in the substantia nigra and striatum but not in the cortex

immune system
• induction increases microglia numbers by about 17%
• following induction, local microglial activation in the substantia nigra and striatum but not in the cortex

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease DOID:14330 OMIM:607688
OMIM:610297
OMIM:613643
OMIM:614251
OMIM:PS168600
J:132679


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/26/2019
MGI 6.14
The Jackson Laboratory