Mouse Genome Informatics
involves: 129X1/SvJ * BALB/c * C57BL/6J
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• about 33% of mutants develop neuroblastoma in the paraspinal ganglia, but not in the adrenal
• tumors are first detected in the abdomen at 6 weeks of age and arise in the ganglion cells
• tumors show features of neuronal differentiation including dense core neurosecretory vesicles, synaptic junctions and areas of lipids throughout the tumors
• neuroblastomas resemble a class of aggressive human neuroblastoma tumors classified as large cell neuroblastoma and have molecular and cellular features of Stage 4 NMYC amplified human neuroblastoma
• 10% of tumors exhibit an arrest in growth between weeks 8-10 which last about 2 weeks and is followed by complete regression of tumors

Mouse Models of Human Disease
Neuroblastoma, Susceptibility to 256700 J:172448