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Phenotypes Associated with This Genotype
involves: 129X1/SvJ * BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Th-MYCN)41Waw mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• about 33% of mutants develop neuroblastoma in the paraspinal ganglia, but not in the adrenal
• tumors are first detected in the abdomen at 6 weeks of age and arise in the ganglion cells
• tumors show features of neuronal differentiation including dense core neurosecretory vesicles, synaptic junctions and areas of lipids throughout the tumors
• neuroblastomas resemble a class of aggressive human neuroblastoma tumors classified as large cell neuroblastoma and have molecular and cellular features of Stage 4 NMYC amplified human neuroblastoma
• 10% of tumors exhibit an arrest in growth between weeks 8-10 which last about 2 weeks and is followed by complete regression of tumors

Mouse Models of Human Disease
OMIM ID Ref(s)
Neuroblastoma, Susceptibility to 256700 J:172448

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory