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Phenotypes Associated with This Genotype
Genotype
MGI:5009552
Allelic
Composition
Nf1tm1Tyj/Nf1+
Tg(Th-MYCN)41Waw/0
Genetic
Background
involves: 129S2/SvPas * BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Tyj mutation (3 available); any Nf1 mutation (85 available)
Tg(Th-MYCN)41Waw mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants exhibit a decreased latency and an increased incidence of tumors compared to single hemizygous Tg(Th-MYCN)41Waw mice, such that about 75% of mutants develop neuroblastomas by 10 months of age compared to 40% of single hemizygous Tg(Th-MYCN)41Waw mice

neoplasm
• mutants exhibit a decreased latency and an increased incidence of tumors compared to single hemizygous Tg(Th-MYCN)41Waw mice, such that about 75% of mutants develop neuroblastomas by 10 months of age compared to 40% of single hemizygous Tg(Th-MYCN)41Waw mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Neuroblastoma, Susceptibility to 256700 J:41126


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory