Mouse Genome Informatics
tg
    Tg(Rbp3-SV40)IT-2Jjw/?
involves: BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• mice develop ocular tumors of photoreceptor cell origin
• beginning at 4 weeks of age, photoreceptor cells are replaced by hyperchromatic cells of small size with scanty cytoplasm
• by 10 weeks of age tumors invade the optic nerve, ciliary body, iris and vitreous
• 25% of mice develop midbrain tumors
• by 2 weeks of age the pineal gland is replaced by tumor cells that resemble a highly differentiated retinoblastoma in 2 week old mice
• cells are large and atypical with numerous abnormal mitotic figures
• tumor cells form Homer Wright rosettes
• by 8-10 weeks of age tumors cover and invade the cerebral and cerebellar hemispheres

vision/eye
• 4 week old mice exhibit cataracts
• mice develop exophthalmia by 8 weeks of age
• mice exhibit narrowing of the ocular fissures by 3 to 4 weeks of age
• beginning in the inner nuclear layer, neoplastic cells invade the bipolar layer of the retina by 6-8 weeks of age

endocrine/exocrine glands
• pineal gland is consistently enlarged by 5 to 6 weeks of age
• pineal gland is replaced by tumor cells

nervous system
• pineal gland is consistently enlarged by 5 to 6 weeks of age
• pineal gland is replaced by tumor cells

Mouse Models of Human Disease
OMIM IDRef(s)
Retinoblastoma; RB1 180200 J:60231