Mouse Genome Informatics
ht
    Men1tm1Zqw/Men1+
involves: 129/Sv * 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• gastrointestinal lesions were seen in 8/49 heterozygous mice, mainly situated in the duodenum or at the junction of the glandular stomach and duodenum
• histological examination of gastrointestinal lesions revealed adenomas and carcinomas in the duodenum
• histological examination of gastrointestinal lesions revealed adenomas in the duodenum
• gastrinomas in the duodenum
• histological examination of gastrointestinal lesions revealed adenomas and carcinomas in the glandular stomach
• tumors located in the mucosa of the bodyfunds glandular stomach were composed of uniform cells with scanty cytoplasma and invaded the submucosa layer
• gastrinomas in the glandular stomach
• in heterozygous mice older than 13 months of age, a high incidence of multiple endocrine tumors was noted, and nearly all mice developed more than one endocrine tumor
• adenomas are first seen at 12 months of age and were detected in 7/17 (41%) heterozygous mice in the 13- to 18-month age group and 21/33 (64%) mice over 19 months
• histological analysis of 23 glands in homozygous mice showed nodular hyperplasia in two (9%) at 8-12 months of age
• at 13-18 months of age, 7/31 (23%) homozygous mice exhibited nodular hyperplasia
• histological analysis of 23 glands in homozygous mice showed adenomas in three (13%) at 8-12 months of age
• at 13-18 months of age, 4/31 (13%) heterozygous mice developed adrenal adenomas
• after 18 months, heterozygous mice developed adenomas in the adrenal cortex
• after 18 months, 28/61 (46%) heterozygous mice developed adenomas or carcinomas in the adrenal cortex
• 3/36 heterozygous female mice over 18 months of age exhibited mammary gland carcinomas
• islet hyperplasia is seen by eight months of age
• at 8-12 months of age, 15 of 23 (65%) mice contained hyperplastic or dysplastic islets
• in 4/12 islet tumors analyzed, two hormones were expresssed simultaneously, such as insulin and glucagon, or glucagon and gastrin, suggesting a mixed hormone production
• at 8-12 months of age, 5/23 (22%) developed islet adenomas
• islet tumors in 6/12 mice showed strong glucagon immunoreactivity, showing alpha-cell tumors or glucagonomas
• the majority of the islet tumors expressed high levels of insulin and were thus identified as beta-cell insulinomas
• at 8-12 months of age, 2/23 developed (9%) carcinomas
• 13/34 mice develop islet carcinomas at 13-18 months of age
• pituitary tumors occur after the age of 18 months and are more common in females (79%)
• 6/15 pituitary tumors showed strong GH immunoreactivity
• however, all pituitary tumors were negative for ACTH staining
• 9/15 pituitary tumors showed strong exclusive PRL immunoreactivity
• seen in 4/61 heterozygous mice
• thyroid follicular cell hyperplasia localized focally, and solid follicular cell carcinomas contained tumor cells in densely packed nest and forming a few minute follicles
• heterozygous mutant mice developed a high frequency of tumors in the gonad
• 9/12 (75%) male heterozygous mice at 8-12 months of age exhibited gonadal stromal hyperplasia or dysplasia and 3/12 (25%) exhibited stromal cell tumors, with the tumor incidence reaching 59% and 88% in the 13- to 18-month and 19- to 26-month age groups,espectively
• 19/44 (43%) of heterozygous females developed ovarian tumors between the ages of 13 and 26 months (J:85302)
• histological analysis of these tumors revealed that all were derived from sex-cord stromal cells, mainly granulosa cells, contained large round nuclei; the follicular structure was largely replaced by the tumor mass, and tumor cells expressed high levels of 3beta-HSD, indicating steroidogenesis in the tumor cells (J:85302)
• the focal stromal hyperplasia and multinodular tumors were seen and were frequently bilateral, compressed the surrounding seminiferous tubules, resulting in degenerative changes (J:85302)
• testis tumor cells were large and often polygonal, with an abundant granular eosinophilic cytoplasm and a central round nucleus, and occasionally contained lipid pigment and vacuoles (J:85302)
• testes of heterozygous mice contained hyperplastic stromal cells and tumors, both with strong 3beta-HSD expression, a marker for Leydig cells (J:85302)

endocrine/exocrine glands
• an enlargement of adrenal glands, often bilateral, is observed in heterozygous mice
• enlarged pituitary was often found in heterozygous mice beyond 13 months of age
• a marked increase in ovarian size in heterozygous mice after 13 months of age (J:85302)
• a marked increase in ovarian size in heterozygous mice after 13 months of age (J:85302)
• seen in 4/61 heterozygous mice

nervous system
• enlarged pituitary was often found in heterozygous mice beyond 13 months of age

reproductive system
• a marked increase in ovarian size in heterozygous mice after 13 months of age (J:85302)
• a marked increase in ovarian size in heterozygous mice after 13 months of age (J:85302)

Mouse Models of Human Disease
OMIM IDRef(s)
Hyperparathyroidism 1; HRPT1 145000 J:85302
Multiple Endocrine Neoplasia, Type I; MEN1 131100 J:85302
Pituitary Adenoma, Growth Hormone-Secreting 102200 J:85302
Pituitary Adenoma, Prolactin-Secreting 600634 J:85302
Thyroid Carcinoma, Follicular; FTC 188470 J:85302