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Phenotypes Associated with This Genotype
Genotype
MGI:5009321
Allelic
Composition
Men1tm1Zqw/Men1+
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Men1tm1Zqw mutation (2 available); any Men1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• 3/36 heterozygous female mice over 18 months of age exhibited mammary gland carcinomas

digestive/alimentary system
• gastrointestinal lesions were seen in 8/49 heterozygous mice, mainly situated in the duodenum or at the junction of the glandular stomach and duodenum
• histological examination of gastrointestinal lesions revealed adenomas and carcinomas in the duodenum
• histological examination of gastrointestinal lesions revealed adenomas in the duodenum
• gastrinomas in the duodenum
• histological examination of gastrointestinal lesions revealed adenomas and carcinomas in the glandular stomach
• tumors located in the mucosa of the bodyfunds glandular stomach were composed of uniform cells with scanty cytoplasma and invaded the submucosa layer
• gastrinomas in the glandular stomach

neoplasm
• gastrointestinal lesions were seen in 8/49 heterozygous mice, mainly situated in the duodenum or at the junction of the glandular stomach and duodenum
• histological examination of gastrointestinal lesions revealed adenomas and carcinomas in the duodenum
• histological examination of gastrointestinal lesions revealed adenomas in the duodenum
• gastrinomas in the duodenum
• histological examination of gastrointestinal lesions revealed adenomas and carcinomas in the glandular stomach
• tumors located in the mucosa of the bodyfunds glandular stomach were composed of uniform cells with scanty cytoplasma and invaded the submucosa layer
• gastrinomas in the glandular stomach
• in heterozygous mice older than 13 months of age, a high incidence of multiple endocrine tumors was noted, and nearly all mice developed more than one endocrine tumor
• 3/36 heterozygous female mice over 18 months of age exhibited mammary gland carcinomas
• histological analysis of 23 glands in homozygous mice showed nodular hyperplasia in two (9%) at 8-12 months of age
• at 13-18 months of age, 7/31 (23%) homozygous mice exhibited nodular hyperplasia
• after 18 months, 28/61 (46%) heterozygous mice developed adenomas or carcinomas in the adrenal cortex
• histological analysis of 23 glands in homozygous mice showed adenomas in three (13%) at 8-12 months of age
• at 13-18 months of age, 4/31 (13%) heterozygous mice developed adrenal adenomas
• after 18 months, heterozygous mice developed adenomas in the adrenal cortex
• islet hyperplasia is seen by eight months of age
• at 8-12 months of age, 15 of 23 (65%) mice contained hyperplastic or dysplastic islets
• in 4/12 islet tumors analyzed, two hormones were expresssed simultaneously, such as insulin and glucagon, or glucagon and gastrin, suggesting a mixed hormone production
• at 8-12 months of age, 5/23 (22%) developed islet adenomas
• islet tumors in 6/12 mice showed strong glucagon immunoreactivity, showing alpha-cell tumors or glucagonomas
• the majority of the islet tumors expressed high levels of insulin and were thus identified as beta-cell insulinomas
• at 8-12 months of age, 2/23 developed (9%) carcinomas
• 13/34 mice develop islet carcinomas at 13-18 months of age
• adenomas are first seen at 12 months of age and were detected in 7/17 (41%) heterozygous mice in the 13- to 18-month age group and 21/33 (64%) mice over 19 months
• pituitary tumors occur after the age of 18 months and are more common in females (79%)
• 6/15 pituitary tumors showed strong GH immunoreactivity
• however, all pituitary tumors were negative for ACTH staining
• 9/15 pituitary tumors showed strong exclusive PRL immunoreactivity
• seen in 4/61 heterozygous mice
• thyroid follicular cell hyperplasia localized focally, and solid follicular cell carcinomas contained tumor cells in densely packed nest and forming a few minute follicles
• heterozygous mutant mice developed a high frequency of tumors in the gonad
• 9/12 (75%) male heterozygous mice at 8-12 months of age exhibited gonadal stromal hyperplasia or dysplasia and 3/12 (25%) exhibited stromal cell tumors, with the tumor incidence reaching 59% and 88% in the 13- to 18-month and 19- to 26-month age groups,espectively
• 19/44 (43%) of heterozygous females developed ovarian tumors between the ages of 13 and 26 months
• histological analysis of these tumors revealed that all were derived from sex-cord stromal cells, mainly granulosa cells, contained large round nuclei; the follicular structure was largely replaced by the tumor mass, and tumor cells expressed high levels of 3beta-HSD, indicating steroidogenesis in the tumor cells
• the focal stromal hyperplasia and multinodular tumors were seen and were frequently bilateral, compressed the surrounding seminiferous tubules, resulting in degenerative changes
• testis tumor cells were large and often polygonal, with an abundant granular eosinophilic cytoplasm and a central round nucleus, and occasionally contained lipid pigment and vacuoles
• testes of heterozygous mice contained hyperplastic stromal cells and tumors, both with strong 3beta-HSD expression, a marker for Leydig cells

endocrine/exocrine glands
• an enlargement of adrenal glands, often bilateral, is observed in heterozygous mice
• enlarged pituitary was often found in heterozygous mice beyond 13 months of age
• seen in 4/61 heterozygous mice
• a marked increase in ovarian size in heterozygous mice after 13 months of age
• a marked increase in ovarian size in heterozygous mice after 13 months of age
• in heterozygous mice older than 13 months of age, a high incidence of multiple endocrine tumors was noted, and nearly all mice developed more than one endocrine tumor
• 3/36 heterozygous female mice over 18 months of age exhibited mammary gland carcinomas
• histological analysis of 23 glands in homozygous mice showed nodular hyperplasia in two (9%) at 8-12 months of age
• at 13-18 months of age, 7/31 (23%) homozygous mice exhibited nodular hyperplasia
• after 18 months, 28/61 (46%) heterozygous mice developed adenomas or carcinomas in the adrenal cortex
• histological analysis of 23 glands in homozygous mice showed adenomas in three (13%) at 8-12 months of age
• at 13-18 months of age, 4/31 (13%) heterozygous mice developed adrenal adenomas
• after 18 months, heterozygous mice developed adenomas in the adrenal cortex
• 19/44 (43%) of heterozygous females developed ovarian tumors between the ages of 13 and 26 months
• histological analysis of these tumors revealed that all were derived from sex-cord stromal cells, mainly granulosa cells, contained large round nuclei; the follicular structure was largely replaced by the tumor mass, and tumor cells expressed high levels of 3beta-HSD, indicating steroidogenesis in the tumor cells
• islet hyperplasia is seen by eight months of age
• at 8-12 months of age, 15 of 23 (65%) mice contained hyperplastic or dysplastic islets
• in 4/12 islet tumors analyzed, two hormones were expresssed simultaneously, such as insulin and glucagon, or glucagon and gastrin, suggesting a mixed hormone production
• at 8-12 months of age, 5/23 (22%) developed islet adenomas
• islet tumors in 6/12 mice showed strong glucagon immunoreactivity, showing alpha-cell tumors or glucagonomas
• the majority of the islet tumors expressed high levels of insulin and were thus identified as beta-cell insulinomas
• at 8-12 months of age, 2/23 developed (9%) carcinomas
• 13/34 mice develop islet carcinomas at 13-18 months of age
• adenomas are first seen at 12 months of age and were detected in 7/17 (41%) heterozygous mice in the 13- to 18-month age group and 21/33 (64%) mice over 19 months
• pituitary tumors occur after the age of 18 months and are more common in females (79%)
• 6/15 pituitary tumors showed strong GH immunoreactivity
• however, all pituitary tumors were negative for ACTH staining
• 9/15 pituitary tumors showed strong exclusive PRL immunoreactivity
• the focal stromal hyperplasia and multinodular tumors were seen and were frequently bilateral, compressed the surrounding seminiferous tubules, resulting in degenerative changes
• testis tumor cells were large and often polygonal, with an abundant granular eosinophilic cytoplasm and a central round nucleus, and occasionally contained lipid pigment and vacuoles
• testes of heterozygous mice contained hyperplastic stromal cells and tumors, both with strong 3beta-HSD expression, a marker for Leydig cells
• seen in 4/61 heterozygous mice
• thyroid follicular cell hyperplasia localized focally, and solid follicular cell carcinomas contained tumor cells in densely packed nest and forming a few minute follicles

nervous system
• enlarged pituitary was often found in heterozygous mice beyond 13 months of age
• pituitary tumors occur after the age of 18 months and are more common in females (79%)
• 6/15 pituitary tumors showed strong GH immunoreactivity
• however, all pituitary tumors were negative for ACTH staining
• 9/15 pituitary tumors showed strong exclusive PRL immunoreactivity

reproductive system
• a marked increase in ovarian size in heterozygous mice after 13 months of age
• a marked increase in ovarian size in heterozygous mice after 13 months of age
• heterozygous mutant mice developed a high frequency of tumors in the gonad
• 9/12 (75%) male heterozygous mice at 8-12 months of age exhibited gonadal stromal hyperplasia or dysplasia and 3/12 (25%) exhibited stromal cell tumors, with the tumor incidence reaching 59% and 88% in the 13- to 18-month and 19- to 26-month age groups,espectively
• 19/44 (43%) of heterozygous females developed ovarian tumors between the ages of 13 and 26 months
• histological analysis of these tumors revealed that all were derived from sex-cord stromal cells, mainly granulosa cells, contained large round nuclei; the follicular structure was largely replaced by the tumor mass, and tumor cells expressed high levels of 3beta-HSD, indicating steroidogenesis in the tumor cells
• the focal stromal hyperplasia and multinodular tumors were seen and were frequently bilateral, compressed the surrounding seminiferous tubules, resulting in degenerative changes
• testis tumor cells were large and often polygonal, with an abundant granular eosinophilic cytoplasm and a central round nucleus, and occasionally contained lipid pigment and vacuoles
• testes of heterozygous mice contained hyperplastic stromal cells and tumors, both with strong 3beta-HSD expression, a marker for Leydig cells


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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory