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Phenotypes Associated with This Genotype
Genotype
MGI:5008587
Allelic
Composition		 Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte
Ptentm1Hwu/Ptentm1Hwu
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (942 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:170965 )
• tamoxifen-treated mice survive 57 days unlike control mice

immune system
enlarged spleen ( J:170965 )
• in tamoxifen-treated mice
increased spleen weight ( J:170965 )
• in tamoxifen-treated mice
increased memory B cell number ( J:170965 )
• in tamoxifen-treated mice
decreased B cell number ( J:170965 )
• in tamoxifen-treated mice
enlarged lymph nodes ( J:170965 )
• in tamoxifen-treated mice

neoplasm
increased acute lymphoblastic leukemia incidence ( J:170965 )
• tamoxifen-treated mice develop T cell acute lymphoblastic leukemia unlike control mice

behavior/neurological
hunched posture ( J:170965 )
• in tamoxifen-treated mice

growth/size/body
weight loss ( J:170965 )
• in tamoxifen-treated mice
enlarged spleen ( J:170965 )
• in tamoxifen-treated mice
increased spleen weight ( J:170965 )
• in tamoxifen-treated mice

integument
disheveled coat ( J:170965 )
• scruffy coat in tamoxifen-treated mice

hematopoietic system
enlarged spleen ( J:170965 )
• in tamoxifen-treated mice
increased spleen weight ( J:170965 )
• in tamoxifen-treated mice
increased memory B cell number ( J:170965 )
• in tamoxifen-treated mice
decreased B cell number ( J:170965 )
• in tamoxifen-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory