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Phenotypes Associated with This Genotype
Genotype
MGI:5007716
Allelic
Composition
Tg(Fabp4-TLE3)#aPton/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• impaired ability to respond to cold exposure
• modest when fed a high-fat diet (J:172245)
• when housed in metabolic cages (J:198134)
• mice fed a high-fat diet exhibit improved glucose homeostasis compared with wild-type mice
• however, mice fed a standard chow diet exhibit normal glucose homeostasis
• in fasting mice when fed a high-fat diet
• when fed a high-fat diet
• when fed a high-fat diet
• when fed a high-fat diet, mice exhibit increased plasma levels of adiponectin and resistin compared with wild-type mice
• however, leptin levels are normal
• when fed a high-fat diet
• when fed a high-fat diet

adipose tissue
• brown adipose tissue exhibits an increase in the number of cells with large unilocular lipid droplets similar to white adipose tissue unlike in wild-type mice
• when fed a high-fat diet

liver/biliary system
• when fed a high-fat diet

behavior/neurological
• when fed a high-fat diet (J:172245)
• when housed in metabolic cages (J:198134)
• when housed in metabolic cages


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory