Phenotypes Associated with This Genotype

Genotype
MGI:5007632

• Allelic Composition: Plxna4^tm1Matl/Plxna4^tm1Matl
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neurite morphology ( J:172268 )

• dopaminergic amacrine cells extend aberrant processes into the S4/S5 sublamina of the inner plexiform layer unlike in wild-type mice

• calbindin+ cells extend processes into the S4/S5 sublamina of the IPL of the retina and exhibit abnormal arborization unlike in wild-type mice

• M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs) exhibit aberrant dendritic arborization in the S4/S5 sublamina of the inner plexiform layer (IPL) and stratification within S1 of the IPL unlike in wild-type mice

• aberrant dopaminergic amacrine cell processes co-localize with M1-type ipRGC dendrites

• however, other subtypes of retinal ganglion and amacrine cells exhibit normal neurite arborization and neurite fasciculation of retinal cells types is normal

abnormal amacrine cell morphology ( J:172268 )

• dopaminergic amacrine cells extend aberrant processes into the S4/S5 sublamina of the inner plexiform layer unlike in wild-type mice

abnormal retina ganglion cell morphology ( J:172268 )

• M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs) exhibit aberrant dendritic arborization in the S4/S5 sublamina of the inner plexiform layer (IPL) and stratification within S1 of the IPL unlike in wild-type mice

• aberrant dopaminergic amacrine cell processes co-localize with M1-type ipRGC dendrites

• however, other subtypes of retinal ganglion and amacrine cells exhibit normal neurite arborization

vision/eye

abnormal amacrine cell morphology ( J:172268 )

• dopaminergic amacrine cells extend aberrant processes into the S4/S5 sublamina of the inner plexiform layer unlike in wild-type mice

abnormal retina ganglion cell morphology ( J:172268 )

• M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs) exhibit aberrant dendritic arborization in the S4/S5 sublamina of the inner plexiform layer (IPL) and stratification within S1 of the IPL unlike in wild-type mice

• aberrant dopaminergic amacrine cell processes co-localize with M1-type ipRGC dendrites

• however, other subtypes of retinal ganglion and amacrine cells exhibit normal neurite arborization