Phenotypes Associated with This Genotype

Genotype
MGI:5002699

• Allelic Composition: Pdcd10^tm1Wami/Pdcd10^tm1Wami; Emx1^tm1(cre)Krj/Emx1⁺
• Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:170480 )

N • mice exhibit normal survival to adulthood

nervous system

abnormal brain vasculature morphology ( J:170480 )

• 80% of mice 7 months or older develop vascular lesions in the forebrain unlike control mice

astrocytosis ( J:170480 )

• starting in early postnatal stages

increased brain size ( J:170480 )

neoplasm

increased hemangioma incidence ( J:170480 )

• 80% of mice 7 months or older develop vascular lesions in the forebrain unlike control mice

cardiovascular system

abnormal brain vasculature morphology ( J:170480 )

• 80% of mice 7 months or older develop vascular lesions in the forebrain unlike control mice

cellular

astrocytosis ( J:170480 )

• starting in early postnatal stages