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Phenotypes Associated with This Genotype
Genotype
MGI:5002697
Allelic
Composition
Pdcd10tm1Wami/Pdcd10tm1Wami
Tg(GFAP-cre)25Mes/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd10tm1Wami mutation (0 available); any Pdcd10 mutation (18 available)
Tg(GFAP-cre)25Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice do not survive beyond 12 months of age
• 80% of rate die by 4 weeks

nervous system
• abnormal cytoarchitecture
• brain capillaries are dilated and less organized and dense than in control mice
• between 3 weeks and 12 months, two-thirds of mice develop cerebrovascular lesions resembling cavernomas unlike in control mice
• at 2 months
• starting in early postnatal stages
• astrocyte proliferation is increased compared to in control cells
• astrocytes exhibit resistance to cycloheximide-induced apoptosis compared with control cells
• retinal astrocyte spreading is decreased compared to in control mice

cardiovascular system
• brain capillaries are dilated and less organized and dense than in control mice
• between 3 weeks and 12 months, two-thirds of mice develop cerebrovascular lesions resembling cavernomas unlike in control mice
• endothelial cell migration is delayed compared to in control mice
• brain capillaries

neoplasm
• between 3 weeks and 12 months, two-thirds of mice develop cerebrovascular lesions resembling cavernomas unlike in control mice
• mice develop cavernomas in the spinal cord unlike wild-type mice

behavior/neurological
• unsteady

growth/size/body

cellular
• endothelial cell migration is delayed compared to in control mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cerebral cavernous malformation 3 DOID:0060671 OMIM:603285
J:170480


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory