Mouse Genome Informatics
hm
    Id3tm1Zhu/Id3tm1Zhu
involves: 129S4/SvJaeSor
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
reproductive system
N
• mice are healthy and fertile (J:44278)

endocrine/exocrine glands
• as early as 2 to 4 months of age
• however, thymectomy rescues defect
• as early as 2 months of age and increasing in severity with age
• aged mice exhibit destruction of lacrimal gland tissue with opaque spots unlike wild-type mice
• as early as 2 months of age prior to eye abnormalities

immune system
N
• peripheral lymphocytes are normal (J:93916)
• as early as 2 months of age and increasing in severity with age
• as early as 2 months of age prior to eye abnormalities
• at 1 year of age, mice exhibit increased levels of SSA and SSB autoantibodies compared with wild-type mice

vision/eye
• as early as 2 months of age prior to eye abnormalities
• at 6 to 10 months of age, 13 of 102 mice exhibit difficulties in maintaining fully opened eyelids due to skin lesions around the eyes unlike wild-type mice
• after 1 year, 35 of 41 mice exhibit eye abnormalities compared with wild-type mice
• aged mice exhibit destruction of lacrimal gland tissue with opaque spots unlike wild-type mice
• as early as 2 to 4 months of age, mice exhibit reduced tear production compared with wild-type mice
• however, thymectomy rescues defect

digestive/alimentary system
• as early as 2 to 4 months of age
• however, thymectomy rescues defect
• as early as 2 months of age and increasing in severity with age

homeostasis/metabolism
• as early as 2 to 4 months of age
• however, thymectomy rescues defect

Mouse Models of Human Disease
OMIM IDRef(s)
Sjogren Syndrome 270150 J:93916