Phenotypes Associated with This Genotype

Genotype
MGI:5000526

• Allelic Composition: Id3^tm1Zhu/Id3^tm1Zhu
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:44278 )

N • mice are healthy and fertile

endocrine/exocrine glands

decreased salivation ( J:93916 )

• as early as 2 to 4 months of age

• however, thymectomy rescues defect

salivary gland inflammation ( J:93916 )

• as early as 2 months of age and increasing in severity with age

abnormal lacrimal gland morphology ( J:93916 )

• aged mice exhibit destruction of lacrimal gland tissue with opaque spots unlike wild-type mice

lacrimal gland inflammation ( J:93916 )

• as early as 2 months of age prior to eye abnormalities

immune system

immune system phenotype ( J:93916 )

N • peripheral lymphocytes are normal

salivary gland inflammation ( J:93916 )

• as early as 2 months of age and increasing in severity with age

lacrimal gland inflammation ( J:93916 )

• as early as 2 months of age prior to eye abnormalities

increased autoantibody level ( J:93916 )

• at 1 year of age, mice exhibit increased levels of SSA and SSB autoantibodies compared with wild-type mice

vision/eye

lacrimal gland inflammation ( J:93916 )

• as early as 2 months of age prior to eye abnormalities

abnormal eye morphology ( J:93916 )

• at 6 to 10 months of age, 13 of 102 mice exhibit difficulties in maintaining fully opened eyelids due to skin lesions around the eyes unlike wild-type mice

• after 1 year, 35 of 41 mice exhibit eye abnormalities compared with wild-type mice

abnormal lacrimal gland morphology ( J:93916 )

• aged mice exhibit destruction of lacrimal gland tissue with opaque spots unlike wild-type mice

decreased tear production ( J:93916 )

• as early as 2 to 4 months of age, mice exhibit reduced tear production compared with wild-type mice

• however, thymectomy rescues defect

digestive/alimentary system

decreased salivation ( J:93916 )

• as early as 2 to 4 months of age

• however, thymectomy rescues defect

salivary gland inflammation ( J:93916 )

• as early as 2 months of age and increasing in severity with age

homeostasis/metabolism

decreased salivation ( J:93916 )

• as early as 2 to 4 months of age

• however, thymectomy rescues defect

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sjogren's syndrome		DOID:12894	OMIM:270150	J:93916