Phenotypes Associated with This Genotype

Genotype
MGI:5000477

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺; Tg(MMTV-cre)#Tfln/0
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:170898 )

• survival time is increased compared to mutant mice carrying Tg(MMTV-cre)1Mam

neoplasm

increased tumor incidence ( J:170898 )

• develop a less diverse set of tumors compared to mutant mice carrying Tg(MMTV-cre)1Mam

increased mammary gland tumor incidence ( J:170898 )

• start to develop by 5 months of age in both virgin and multiparous mice

• 69% of mice have palpable mammary tumors at the time of death

• tumors are typically either adenosquamous carcinoma or adenomyoepithioma

• isolated lung metastases are seen in rare cases

increased mammary adenocarcinoma incidence ( J:170898 )

integument

increased mammary gland tumor incidence ( J:170898 )

• start to develop by 5 months of age in both virgin and multiparous mice

• 69% of mice have palpable mammary tumors at the time of death

• tumors are typically either adenosquamous carcinoma or adenomyoepithioma

• isolated lung metastases are seen in rare cases

increased mammary adenocarcinoma incidence ( J:170898 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:170898 )

• start to develop by 5 months of age in both virgin and multiparous mice

• 69% of mice have palpable mammary tumors at the time of death

• tumors are typically either adenosquamous carcinoma or adenomyoepithioma

• isolated lung metastases are seen in rare cases

increased mammary adenocarcinoma incidence ( J:170898 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:170898