Mouse Genome Informatics
cn
    Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Tg(MMTV-cre)4Mam/0

involves: 129S6/SvEvTac * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• survival time is increased compared to mutant mice carrying Tg(MMTV-cre)1Mam

tumorigenesis
• develop a less diverse set of tumors compared to mutant mice carrying Tg(MMTV-cre)1Mam
• start to develop by 5 months of age in both virgin and multiparous mice
• 69% of mice have palpable mammary tumors at the time of death
• tumors are typically either adenosquamous carcinoma or adenomyoepithioma
• isolated lung metastases are seen in rare cases

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:170898