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Phenotypes Associated with This Genotype
Genotype
MGI:5000279
Allelic
Composition
Tg(AR*100Q)C25Als/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die of unknown causes at 15 to 22 months of age

behavior/neurological
• at 14 months, mice exhibit impaired mobility and difficulty walking compared with control mice
• at 11 months, mice exhibit decreased latency to fall on a wire hanging test compared with control mice
• at 13 months, male mice exhibit impaired gait compared with control mice
• at 26 months, female mice exhibit impaired gait compared with control mice
• at 11 months
• at 17 months, male mice exhibit hindlimb paralysis unlike control mice
• however, female mice do not exhibit severe hindlimb paralysis

muscle
• mice exhibit nuclear inclusions in the liver and muscle unlike in control mice
• at 13 months, male mice exhibit hindlimb atrophy unlike control mice
• at 17 months, male mice exhibit severe hindlimb atrophy unlike control mice
• at 26 months, female mice exhibit hindlimb atrophy unlike control mice
• however, female mice do not exhibit severe hindlimb atrophy
• mice exhibit proximal muscle weakness that accompanies weight loss unlike control mice

growth/size/body
• beginning at 8 months of age in male mice and 17 months of age in female mice
• beginning at 8 months of age in male mice and 17 months of age in female mice
• at 8 months of age

nervous system
• at 14 months

liver/biliary system
• mice exhibit nuclear inclusions in the liver and muscle unlike in control mice

skeleton

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Kennedy's disease DOID:0060161 OMIM:313200
J:89772


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory