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Phenotypes Associated with This Genotype
Genotype
MGI:5000247
Allelic
Composition
Boctm2Rsk/Boctm2Rsk
Cdontm1Rsk/Cdontm1Rsk
Genetic
Background
B6.129-Boctm2Rsk Cdontm1Rsk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Boctm2Rsk mutation (0 available); any Boc mutation (26 available)
Cdontm1Rsk mutation (0 available); any Cdon mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• display a range of holoprosencephalic phenotypes

craniofacial
N
• do not display cyclopia
• Background Sensitivity: unlike mice on a 129 background, mice on a C57BL/6 background display cleft lip
• proboscis like nose

vision/eye

limbs/digits/tail
N
• do not display digit patterning defects unlike Shh null mice

growth/size/body
• Background Sensitivity: unlike mice on a 129 background, mice on a C57BL/6 background display cleft lip
• proboscis like nose

Mouse Models of Human Disease
OMIM ID Ref(s)
Holoprosencephaly 11; HPE11 614226 J:171767


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory