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Phenotypes Associated with This Genotype
Genotype
MGI:5000121
Allelic
Composition
Git1Gt(FHCRC-GT-S10-12C1)Sor/Git1Gt(FHCRC-GT-S10-12C1)Sor
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Git1Gt(FHCRC-GT-S10-12C1)Sor mutation (2 available); any Git1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of mice die postnatally (J:171608)
• 50% of mice die postnatally (J:171608)

behavior/neurological
• mice spend less time with a novel object compared with wild-type mice (J:171608)
• however, amphetamine treatment normalizes impaired memory (J:171608)
• mice spend less time with a novel object compared with wild-type mice (J:171608)
• however, amphetamine treatment normalizes impaired memory (J:171608)
• in a Morris water maze, mice exhibit impaired learning compared with wild-type mice (J:171608)
• in a Morris water maze, mice exhibit impaired learning compared with wild-type mice (J:171608)
• mice exhibit reduced swimming velocity compared with wild-type mice (J:171608)
• mice exhibit reduced swimming velocity compared with wild-type mice (J:171608)
• in a home cage at 8 weeks of age (J:171608)
• 2-fold in an open field at 8 weeks of age (J:171608)
• however, 7 month old mice exhibit normal locomotor activity and amphetamine-treatment normalizes hyperactivity (J:171608)
• 2-fold in an open field at 8 weeks of age (J:171608)
• in a home cage at 8 weeks of age (J:171608)
• however, 7 month old mice exhibit normal locomotor activity and amphetamine-treatment normalizes hyperactivity (J:171608)

nervous system
• the number of parvalbumin neurons in the hippocampal area and cortex is reduced compared to in wild-type mice (J:171608)
• the number of parvalbumin neurons in the hippocampal area and cortex is reduced compared to in wild-type mice (J:171608)
• mice exhibit enhanced theta rhythms compared with wild-type mice (J:171608)
• however, amphetamine treatment reversed elevated theta rhythms (J:171608)
• mice exhibit enhanced theta rhythms compared with wild-type mice (J:171608)
• however, amphetamine treatment reversed elevated theta rhythms (J:171608)
• the ratio of field excitatory postsynpatic potential slopes to fiber volley amplitudes is increased compared to in wild-type mice (J:171608)
• however, presynaptic release probability is normal (J:171608)
• the ratio of field excitatory postsynpatic potential slopes to fiber volley amplitudes is increased compared to in wild-type mice (J:171608)
• however, presynaptic release probability is normal (J:171608)
• mice exhibit decreased miniature inhibitory postsynaptic current (mIPSC) frequency compared with wild-type mice (J:171608)
• however, mIPSC amplitude is normal (J:171608)
• mice exhibit decreased miniature inhibitory postsynaptic current (mIPSC) frequency compared with wild-type mice (J:171608)
• however, mIPSC amplitude is normal (J:171608)

growth/size/body
• in surviving mice (J:171608)
• in surviving mice (J:171608)

Mouse Models of Human Disease
OMIM ID Ref(s)
Attention Deficit-Hyperactivity Disorder; ADHD 143465 J:171608


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory