Mouse Genome Informatics
hm
    Git1Gt(FHCRC-GT-S10-12C1)Sor/Git1Gt(FHCRC-GT-S10-12C1)Sor
involves: 129S4/SvJaeSor * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• 50% of mice die postnatally

behavior/neurological
• mice spend less time with a novel object compared with wild-type mice
• however, amphetamine treatment normalizes impaired memory
• in a Morris water maze, mice exhibit impaired learning compared with wild-type mice
• mice exhibit reduced swimming velocity compared with wild-type mice
• 2-fold in an open field at 8 weeks of age
• in a home cage at 8 weeks of age
• however, 7 month old mice exhibit normal locomotor activity and amphetamine-treatment normalizes hyperactivity

nervous system
• the number of parvalbumin neurons in the hippocampal area and cortex is reduced compared to in wild-type mice
• mice exhibit enhanced theta rhythms compared with wild-type mice
• however, amphetamine treatment reversed elevated theta rhythms
• the ratio of field excitatory postsynpatic potential slopes to fiber volley amplitudes is increased compared to in wild-type mice
• however, presynaptic release probability is normal
• mice exhibit decreased miniature inhibitory postsynaptic current (mIPSC) frequency compared with wild-type mice
• however, mIPSC amplitude is normal

growth/size/body
• in surviving mice

Mouse Models of Human Disease
OMIM IDRef(s)
Attention Deficit-Hyperactivity Disorder; ADHD 143465 J:171608