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Phenotypes Associated with This Genotype
Genotype
MGI:4999798
Allelic
Composition
Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Guca1atm1.1Hunt mutation (0 available); any Guca1a mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Photoreceptor degeneration in Guca1atm1.1Hunt/Guca1a+ and Guca1atm1.1Hunt/Guca1atm1.1Hunt mice

vision/eye
• at 5 and 12 months
• the rate of photoreceptor loss declines with age
• at 5 months and progressive with age
• at 5 and 12 months
• at 5 and 12 months
• at 5 and 12 months
• mice exhibit impaired rod recovery kinetics from bright flash compared with wild-type mice
• at 5 and 12 months, cone function is reduced with reduced b-wave amplitude compared to in wild-type mice
• 10 Hz and 15 Hz cone flicker electroretinogram is depressed compared to in wild-type mice
• loss of cone response progresses with age
• at 5 and 12 months

nervous system
• at 5 and 12 months
• the rate of photoreceptor loss declines with age
• at 5 months and progressive with age
• at 5 and 12 months
• at 5 and 12 months


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory