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Phenotypes Associated with This Genotype
Genotype
MGI:4999602
Allelic
Composition
Fa2htm1Hama/Fa2htm1Hama
Cnptm1(cre)Kan/Cnp+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnptm1(cre)Kan mutation (0 available); any Cnp mutation (26 available)
Fa2htm1Hama mutation (0 available); any Fa2h mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• histological abnormalities are similar to those in germline null mice
• decrease in myelin lipid levels in the cerebellum compared to controls at 12 months of age but not at 6 months of age
• while the overall number of Purkinje cells is similar to controls, regions with smaller sized or absent Purkinje neurons relative to controls are seen

homeostasis/metabolism
• decrease in myelin lipid levels in the cerebellum compared to controls at 12 months of age but not at 6 months of age
• hFA-GalCer galactolipids are absent from the brain at 10 weeks of age
• total loss of brain hFA-galactolipids at 3 months of age

behavior/neurological
N
• unlike germline null mice, no defects in learning are detected using a water T maze or a morris water maze
• at 12 months of age
• at 12 months of age
• reduction in vertical activity is more severe than that in horizontal activity
• decrease in spontaneous activity at 12 months of age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory