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Phenotypes Associated with This Genotype
Genotype
MGI:4999583
Allelic
Composition
Cryabtm1.1Ady/Cryabtm1.1Ady
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cryabtm1.1Ady mutation (0 available); any Cryab mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Eye and lens abnormalities in Cryabtm1.1Ady/Cryab+ and Cryabtm1.1Ady/Cryabtm1.1Ady mice

vision/eye
• in some mice, not bilateral
• overall in 84% of mice, beginning at 3 to 8 weeks and increasing in stage with age
• in some mice
• in some mice, not bilateral

muscle
• by 10 months, muscles exhibit dark basophilic fibers, internal nuclei, scattered necrosis, and fibrosis with alphabeta-crystallin inclusions unlike wild-type muscles

behavior/neurological

Mouse Models of Human Disease
OMIM ID Ref(s)
Myopathy, Myofibrillar, 2; MFM2 608810 J:171679


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory