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Phenotypes Associated with This Genotype
Genotype
MGI:4950280
Allelic
Composition
Ccl2tm1.1Pame/Ccl2tm1.1Pame
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl2tm1.1Pame mutation (1 available); any Ccl2 mutation (25 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• LPS-treated mice exhibit reduced percent of circulating Ly6Chi monocyte compared with similarly treated wild-type mice
• mice exposed to L. monocytogenes exhibit reduced Ly6Chi monocyte emigration from the bone marrow compared with similarly treated wild-type mice
• mice exposed to L. monocytogenes exhibit reduced Ly6Chi monocyte emigration from the bone marrow and diminished bacterial clearance compared with similarly treated wild-type mice

cellular
• LPS-treated mice exhibit reduced percent of circulating Ly6Chi monocyte compared with similarly treated wild-type mice
• mice exposed to L. monocytogenes exhibit reduced Ly6Chi monocyte emigration from the bone marrow compared with similarly treated wild-type mice

hematopoietic system
• LPS-treated mice exhibit reduced percent of circulating Ly6Chi monocyte compared with similarly treated wild-type mice
• mice exposed to L. monocytogenes exhibit reduced Ly6Chi monocyte emigration from the bone marrow compared with similarly treated wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory