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Phenotypes Associated with This Genotype
Genotype
MGI:4950072
Allelic
Composition
Scn1atm1.1Aesc/Scn1a+
Tg(Eno2-Scn2a1*)Q54Mm/0
Genetic
Background
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn1atm1.1Aesc mutation (0 available); any Scn1a mutation (8 available)
Tg(Eno2-Scn2a1*)Q54Mm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants begin to exhibit spontaneous partial motor seizures and generalized tonic-clonic seizures at P16 (J:170734)
• general seizures last 45-100 seconds, during which time mice experience repetitive jerking of all four limbs and neck, running, and jumping, and tail clonus; seizures often end with tonic hindlimb extension, indicative of a severe seizure (J:170734)
• mutants begin to exhibit spontaneous partial motor seizures and generalized tonic-clonic seizures at P16 (J:170734)
• general seizures last 45-100 seconds, during which time mice experience repetitive jerking of all four limbs and neck, running, and jumping, and tail clonus; seizures often end with tonic hindlimb extension, indicative of a severe seizure (J:170734)
• mutants begin to exhibit generalized tonic-clonic seizures at P16 (J:170734)
• mutants begin to exhibit generalized tonic-clonic seizures at P16 (J:170734)

mortality/aging
• sporadic death begins to occur at P16, with 100% mortality by P24 (J:170734)
• sporadic death begins to occur at P16, with 100% mortality by P24 (J:170734)

nervous system
• mutants begin to exhibit spontaneous partial motor seizures and generalized tonic-clonic seizures at P16 (J:170734)
• general seizures last 45-100 seconds, during which time mice experience repetitive jerking of all four limbs and neck, running, and jumping, and tail clonus; seizures often end with tonic hindlimb extension, indicative of a severe seizure (J:170734)
• mutants begin to exhibit spontaneous partial motor seizures and generalized tonic-clonic seizures at P16 (J:170734)
• general seizures last 45-100 seconds, during which time mice experience repetitive jerking of all four limbs and neck, running, and jumping, and tail clonus; seizures often end with tonic hindlimb extension, indicative of a severe seizure (J:170734)
• mutants begin to exhibit generalized tonic-clonic seizures at P16 (J:170734)
• mutants begin to exhibit generalized tonic-clonic seizures at P16 (J:170734)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory