Analysis Tools
mortality/aging
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• some mice are born alive but die within hours of birth
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• mice are either stillborn or die within hours of birth with all dead by P0.5
• expected numbers are found from E9.5 to E17.5
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cardiovascular system
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• glomeruloid bodies are found in the ventral aspect of the spinal cord
• however, vessels appear normal in the midbrain, hindbrain, dorsal spinal cord, and non nervous system tissues
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• in the pallium vessels form abnormal "glomeruloid-like" bodies adjacent to the perineural vascular plexus
• glomeruloids are detected in the ganglionic eminence as early as E10.5
• at E10.5 vessel sprouting resembles sprouting in wild-type mice at E9.5
• at E11.5 vessel sprouts form small glomeruloids that increase in size with age
• endothelial stalks connect the glomeruliods to the perineural vascular plexus
• glomeruloid structures are typically composed of multiple tufted vascular channels
• however, vessels formed normally along the longitudinal cerebral fissure
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• at E10.5 vessel sprouting in the pallium resembles sprouting in wild-type mice at E9.5
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• increases in severity during development
• seen in most mice
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• at E17.5 bleeding into the outer wall of the telencephalic vesicles with intraventricular blood leakage and enlarged, distorted, lateral ventricles
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• common but with variable severity
• occasionally seen in the absence of intracranial hemorrhage
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• following intracardiac injection, biotin is found in intra- and extravascular regions in the forebrain
• however, no difference in permeability is seen in non-CNS vessels
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• following intracardiac injection, biotin is found in intra- and extravascular regions in the ventral spinal cord
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nervous system
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• in the pallium vessels form abnormal "glomeruloid-like" bodies adjacent to the perineural vascular plexus
• glomeruloids are detected in the ganglionic eminence as early as E10.5
• at E10.5 vessel sprouting resembles sprouting in wild-type mice at E9.5
• at E11.5 vessel sprouts form small glomeruloids that increase in size with age
• endothelial stalks connect the glomeruliods to the perineural vascular plexus
• glomeruloid structures are typically composed of multiple tufted vascular channels
• however, vessels formed normally along the longitudinal cerebral fissure
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• increases in severity during development
• seen in most mice
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• at E17.5 bleeding into the outer wall of the telencephalic vesicles with intraventricular blood leakage and enlarged, distorted, lateral ventricles
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• common but with variable severity
• occasionally seen in the absence of intracranial hemorrhage
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• following intracardiac injection, biotin is found in intra- and extravascular regions in the forebrain
• however, no difference in permeability is seen in non-CNS vessels
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• following intracardiac injection, biotin is found in intra- and extravascular regions in the ventral spinal cord
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hydrocephaly
(
J:171226
)
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• increases in severity during development
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• loose packing of neuroepithelial cells with large open spaces in tissue surrounding glomeruloid bodies
• occasional breaks between cortical marginal glia are present
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• at E15.5 a marked failure of neocortex development is seen
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• notably thinner at E13.5
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• at E17.5 bleeding into the outer wall of the telencephalic vesicles (pallium) with intraventricular blood leakage and enlarged, distorted, lateral ventricles
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